Problem in Diastereoselectivity

Purpose The purpose of this prove is to determine the stereochemical forthcome of a reaction. A second chiral center is being formed in this experiment and two diastereomeric compounds are created. Table of Reagents Safety Precautions or Hazards Do non place pipettes in paper trash. Must be thrown absent in the broken glass container Take caution when adding HCl. CO2 developing may be vigorous so be sure to button move. Never directly heat ethanol over hot plate, practice peeing bath. Conc. H2SO4 is highly corrosive Equations for all Reactions Mechanism(s)Experimental Procedure crack A 1. total a magnetic erect bar, 2g of benzoin, and 20 ml of absolute ethanol in a 125ml Erlenmeyer flask. 2. While stirring, (do not gambling on the heater) carefully add 0. 4 g (10. 6 mmol) of sodium borohydride portion-wise to the confection over 5 winks. After the addition is complete, stir the mixture for another 15 minutes at room temperature. A washcloth precipitate will form. 3. Cool the flask in an ice-water bath and break the excess sodium borohydride by first adding 30 mL of water followed by the careful and dropwise addition of 2 mL of 3M HCl.The HCl addition should be done quite slowly, no more than ab proscribed 3 drops per minute (maybe 10-15 minutes total time). The mixture may foam uncontrollably if the battery- acrid is added too quickly. If the foam reaches the 100 mL mark on the flask, cloture adding HCl until the foaming subsides. 4. When the HCl addition is complete, add another 10 mL of water and stir the mixture for 15 minutes. 5. Collect the white precipitate by sucking filtration. Wash the product diol with water on the suction funnel (about 150 mL) and allow the product to air alter on a filter paper. Safely store the product in your draftsperson until next week. . The filtrate should be placed in the aqueous acidulent waste container. It contains water, B(OH)3, HCl, and ethanol. 7. Then, record the mp when the sample is completely dr y (mp 136-137 ? C). boot out filtrate in the complete waste container. 8. Record the IR spectrum and compare it to the spectrum of the starting benzoin, noting the absence of the carbonyl-stretching band. Your product should be completely dry in the first place going on next week to the next reaction. Part B 1. Dissolve 1 g (4. 67 mmol) of the diol in 15 mL of anhydrous reagent grade acetone in a 50 mL round bottomed flask fitted with a stir bar. . Add 2 mL of acetone dimethyl acetal (2,2-dimethoxypropane). Immediately stopper the flask and chill out it in an ice bath. 3. Remove the stopper and add 12 drops of difficult sulfuric acid. (Caution conc. H2SO4 is highly corrosive). 4. Carefully replace the stopper and continue to stir the cooled flask for 20 minutes. 5. Then, transfer the cold reaction mixture to a separatory funnel. Rinse the reaction flask with two 25 mL portions of diethyl vinyl ether and add the rinses to the separatory funnel. Carefully add 30 mL of Na2CO3 so lution to the separatory funnel.Swirl the funnel gently before inserting its stopper. (Caution CO2 evolution may be vigorous. ) stash away the stopper and immediately invert the funnel and vent it by gap the stopcock. With the stopcock open, swirl the funnel again to complete the neutralization of the acid and evolution of CO2. Close the stopcock. Position the funnel upright and remove the stopper. 6. enfeeble off the dishonor aqueous layer and extract the remaining organic layer with two-30 mL portions of water and then one 30 mL portion of saturated sodium chloride solution. 7.Transfer the organic layer to an Erlenmeyer flask and dry the solution over Na2SO4. DECANT the dry solution into a round-bottom flask and evaporate the solvent on a rotary evaporator (rotovap). Your TA will explain to you how the rotovap works. 8. The aqueous layer should be placed in the aqueous basic waste container. 9. Scrape your crystalline product out of the round-bottomed flask. Dry. If your cryst als are sticky, your TA will assist you by rinse with ice-cold pentane. Record the mp and IR of your product. Be sure to foreshadow a yield for steps 1 and 2 and an overall yield.Results and Observations I noticed that it was very hard to get the solid substance out of the erlinmeyer flask without rinsing several times. I do not cerebrate this gave me abnormal results or is a cause for skewed yield. In vox A I got a resolve point of 122*C and unruffled 1. 427g of product. In position B I got . 4857g of product. My melting point was 49*C and there was no IR taken because the machine was down. crossing Data The product in part A is officially called erythro-1,2-diphenyl-1,2-ethanediol. It has a melting point of 136*C. It has the chemical formula of C14H14O2 and molecular mass of 214. 64 g/mol. The product in part be is officially called meso-2,2-dimethyl-4,5-diphenyl-1,3-dioxolane. The melting point for this is 57*C and has a molecular weight of 254. 329 g/mol. Its chemical fo rmula is C17H18O2 . Discussion of Results My yield was decent but because of the lower than normal melting points Ive determined that my product is not as pure as Id like it to be. Also, I am without an IR spectrum of my product in part B so I cannot analyze my own chemicals stereochemistry. Percent yield and mp MP part A 122*C MP part B 49*C % yield A % yield B % yield Overall